Transcranial Magnetic Stimulation For Visual Snow Syndrome (TMSVS)

University of Colorado Denver (CU Denver)

Status: Completed

Conditions: Visual Snow Syndrome

Treatments: Device: Transcranial Magnetic Stimulation device

Study type: Interventional

Funder types: Other

Identifiers

NCT04925232

20-0424

Details and patient eligibility

About

This study aims to investigate the feasibility of the use of repetitive transcranial magnetic stimulation (rTMS) for symptoms associated with Visual Snow syndrome (VS).

Full description

The study will gather information about the treatment of up to 10 people with VS using rTMS. Treated participants will undergo 10 sessions of rTMS administered 5 times a week over 2 weeks. All visits will take place in the University of Colorado School of Medicine NeuroMag/Transcranial Magnetic Stimulation laboratory on University of Colorado Anschutz Medical Campus.

The specific aims for this feasibility study include:

1. Determine whether any participant experiences untoward effects of rTMS in the setting of visual snow syndrome and determine the potential drop-out rate of larger study.

2. Determine the performance of a novel scale (Colorado Visual Snow Scale) and two three psychophysical visual processing tasks

   1. Determine the standard deviation and test-retest reliability for the novel scale and two visual processing tasks
   2. Determine whether the visual processing tasks perform similar to performance found by the developer

3. Describe changes in outcome measures between pre- and post-treatment with rTMS

Enrollment: 10 patients

Sex: All

Ages: 19 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• A diagnosis of VS that meets International Headache Society criteria
• Able to provide meaningful informed consent
• Visual snow must be present for more than three months and must be persistent (i.e. continuous)
• A prior clinical Brain MRI with and without contrast done in the past 3 years that does not show signs of clinically significant brain lesions (no evidence of multiple sclerosis, stroke, brain tumor, cortical heterotopia or other cortical developmental abnormalities, arteriovenous malformation, etc...)

Exclusion criteria

• Syndrome meeting criteria for Hallucinogen-persisting perception disorder
• Prior treatment with TMS for any disorder
• Epilepsy, family history of epilepsy, or personal history of seizure
• Any medical condition or medication that increases the risk of seizure
• Pacemaker or other implantable medical device
• Metal in the skull, not including the mouth
• Unstable cardiac, pulmonary, or other systemic illness
• Pregnancy
• Bipolar disorder
• History of suicidality

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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10 participants in 1 patient group

One group

Experimental group

Description:

All participants will undergo 2 weeks (5 times each week) of repetitive TMS

Treatment:

Device: Transcranial Magnetic Stimulation device