Transcranial Magnetic Stimulation in Treatment of Attention Deficit/Hyperactivity Disorders

Shalvata Mental Health Center

Status: Unknown

Conditions: Attention Deficit/Hyperactivity Disorder

Treatments: Other: Placebo Treatment; Device: Transcranial Magnetic Stimulation (Magstim, Rapid)

Study type: Interventional

Funder types: Other

Identifiers

NCT01618110

SH-12-0012

Details and patient eligibility

About

• ADHD is one of the most common psychiatric disorders.
• While most of the attention is directed towards youth, 60% continue to suffer symptoms into adult life.
• Current treatment is effective, but 30% suffer side effects that lowers QOL, and 20% are non-responders.
• Known mechanism of pathophysiology includes hypoactive dopaminergic system, especially at right PFC.
• It is this study hypothesis that by stimulating the right PFC by TMS, it will be possible to alleviate ADHD symptoms.
• A 10 sessions of treatment will by applied on a randomly allocated group of patients, diagnosed with ADHD, in a 2:1 ratio: The first group will receive an actual TMS treatment, and the second group will receive a sham treatment.
• Improvement of objective and subjective ADHD scale will be examined.

Enrollment: 30 estimated patients

Sex: All

Ages: 21 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 18-50
• Established diagnosis of ADHD
• No C/I for TMS
• Has signed an informed consent form

Exclusion criteria

• Major Psychiatric disorders (Psychotic or Affective)
• Active use of drugs (4 weeks prior to participation)
• Neurologic disorder such as Epilepsy.
• No use of stimulants during the previous 7 days

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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30 participants in 2 patient groups

Treatment Group

Active Comparator group

Treatment:

Device: Transcranial Magnetic Stimulation (Magstim, Rapid)

Sham group

Sham Comparator group

Description:

Sham TMS coil (same noise, minimal magnetic field)

Treatment:

Other: Placebo Treatment