Transcranial Magnetic Stimulation Theta Burst (TMS), Depression and Smoking.

Dr. Julian Reyes López

Status: Enrolling

Conditions: Major Depressive Disorder; Smoking Reduction

Treatments: Device: Theta Burst Transcranial Magnetic Stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT05694754

21-03-2022

Details and patient eligibility

About

This study evaluates de efficacy of Theta Burst Transcranial Magnetic Stimulation (TMS) applied on the left dorsolateral prefrontal cortex in patients with Major Depressive disorder and tobacco consumption.

Full description

Major Depressive Disorder (MDD) affects 350 million worldwide causing damage on quality of life and risk behavior such as suicide and smoking. smoking is the second leading cause of death causing about 5 million deaths annually. Theta Burst Stimulation (TBS) is a more tolerable protocol administered at lower intensities and shorter intervals than conventional rTMS protocols.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• With dependence on tobacco use, with depressive symptomatology, that they agree to sign the informed consent letter.

Exclusion criteria

• History of head trauma with loss of consciousness, with intracranial metallic objects or metallic plates in the skull, patients with structured suicidal ideation or recent attempts, who suffer from uncontrolled chronic diseases at the time of entering the study (for example: hypertension, diabetes, rheumatic diseases), patients with psychotic symptoms. subjects with alterations in electroencephalogram (epileptiform activity), patients with any type of uncontrolled chronic medical or neurological disease, pregnant women.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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20 participants in 2 patient groups

1 session

Experimental group

Description:

Participants will receive 1 session from monday to friday,during 4 weeks, with 600 total pulses per session

Treatment:

Device: Theta Burst Transcranial Magnetic Stimulation

3 sessions

Experimental group

Description:

Participants will receive 3 sessions from monday to friday,during 4 weeks, with 1800 total pulses per session with a 10 minutes rest interval

Treatment:

Device: Theta Burst Transcranial Magnetic Stimulation