Transcranial Magnetic Stimulation Treatment of Hoarding Disorder
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Details and patient eligibility
About
This is multiple baseline study including up to three participants with a primary diagnosis of hoarding disorder. All patients will receive unblinded repetitive transcranial magnetic stimulation study intervention.
Full description
Study assessments will be conducted at pre-baseline, weekly during baseline assessment (until a stable baseline is established, but not less than 2, 4, and 6 weeks for patients respectively), weekly during treatment, and at post-treatment. Magnetic resonance imaging (MRI) will be competed at pre-baseline, pre-treatment, and post-treatment. Treatment will entail daily (5 days/week) sessions of repetitive transcranial magnetic stimulation using the Neurostar Therapy System for 6 weeks employing right-sided, low frequency stimulation (1 Hz, 900 pulses/session for 30 sessions, 27,000 total pulses, intensity at 90% of the passive motor threshold) to the dorsolateral prefrontal cortex (DLPFC). Neuronavigation will direct coil placement over the DLPFC based upon structural MRI.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- Diagnosed with hoarding disorder as primary disorder
- Clinical Global Impression Score > 3
- Saving Inventory-Revised score > 39
Exclusion criteria
- Any contraindication for participation in magnetic resonance imaging or transcranial magnetic stimulation
- Severe and/or unstable medical or psychiatric condition that require immediate medical attention
- Diagnosed with current major depressive episode
- Currently taking psychiatric medication
Trial design
Primary purpose
Allocation
Interventional model
Masking
1 participants in 1 patient group
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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