Transcranial Temporal Interference Stimulation In Severely Brain Injured Patients With Disorders of Consciousness

Air Force Military Medical University of People's Liberation Army

Status: Enrolling

Conditions: Unresponsive Wakefulness Syndrome; Severe Brain Injury; Minimally Conscious State; Disorders of Consciousness

Treatments: Device: tTIS

Study type: Interventional

Funder types: Other

Identifiers

NCT06851156

KY20242231jiangwen

Details and patient eligibility

About

The purpose of this academic lead study is to explore the effect of noninvasive neuromodulation of the CM-pf via tTIS for patients with disorders of consciousness.

Enrollment: 10 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• traumatic and nontraumatic etiology of VS/UWS or MCS according to published diagnostic criteria.

Exclusion criteria

• patients in coma, with less than 1 week after acute brain insult, with fluctuating diagnosis on baseline assessment, and with a metallic cerebral implant or pacemaker, and with epilepsy.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

10 participants in 1 patient group

Transcranial Temporal Interference Stimulation

Experimental group

Description:

tTIS is applied over the bilateral CM-pf for 10 days, once a day.

Treatment:

Device: tTIS