Transcranial Treatments in Eating Disorders

University of Colorado Denver (CU Denver)

Status: Terminated

Conditions: Bulimia Nervosa; Anorexia Nervosa

Treatments: Procedure: Transcranial magnetic stimulation; Procedure: Transcranial direct current stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT02535780

13-2716

Details and patient eligibility

About

The primary aim of this study is to study how Repetitive Transcranial Magnetic Stimulation (rTMS) tailored to specific anorexia nervosa (AN) or bulimia nervosa (BN) brain activation alterations will promote recovery and to study how inhibitory tDCS (Transcranial Direct Current Stimulation) will reduce symptoms of body image distortion in a second sample of AN and BN groups.

Enrollment: 1 patient

Sex: Female

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Anorexia Nervosa subjects:
• Meets DSM-5 criteria for anorexia nervosa (AN) either binge-eating/purging type or restricting-type:
• Intense fear of gaining weight or becoming fat, even though underweight.
• The ability to undergo an MRI, fMRI or other similar procedure requiring spending time in an enclosed space
• Bulimia Nervosa subjects:
• Meet DSM-5 criteria for bulimia nervosa (BN):
• Self-induced vomiting; misuse of laxatives, diuretics, enemas, medication, fasting, excessive exercise.

Exclusion criteria

• Electrolyte, blood count or kidney or liver function abnormalities.
• No symptoms of alcohol or other substance abuse or dependence in the past 3 months,
• No previous or current organic brain syndromes, dementia, psychotic disorders, somatization disorders, or conversion disorder, head trauma, indication of mental retardation or pervasive developmental disorder.
• No antipsychotics, tricyclic antidepressants or Wellbutrin or other medication that may lower the seizure threshold.
• Claustrophobia.

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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1 participants in 4 patient groups

TMS Treatment Group

Experimental group

Description:

15 sessions active Transcranial magnetic stimulation (TMS) treatment

Treatment:

Procedure: Transcranial magnetic stimulation

TMS Sham Group

Sham Comparator group

Description:

15 sessions sham Transcranial magnetic stimulation (TMS) treatment

Treatment:

Procedure: Transcranial magnetic stimulation

tDCS Treatment Group

Experimental group

Description:

15 sessions active Transcranial direct current stimulation (tDCS) treatment

Treatment:

Procedure: Transcranial direct current stimulation

tDCS Sham Group

Sham Comparator group

Description:

15 sessions sham Transcranial direct current stimulation (tDCS) treatment

Treatment:

Procedure: Transcranial direct current stimulation