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TRANSCRIBE (Transcriptomic Analysis of Left Ventricular Gene Expression)

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Mass General Brigham

Status

Enrolling

Conditions

Cardiovascular Diseases

Study type

Observational

Funder types

Other
NIH

Identifiers

NCT00985049
R01HL118266 (U.S. NIH Grant/Contract)
2007p002323

Details and patient eligibility

About

Hypothesis: The investigators hypothesize that genetic variants will alter gene expression in response to ischemia during cardiopulmonary bypass. To test this, the investigators will be taking small pieces of heart tissue from patients undergoing heart surgery before and after this period of ischemia. This will be compared to blood gene expression in blood cells and analyzed with the patients' genetic profile. This might allow us to assess the amount of inflammation that occurs when patients are on the heart-lung machine as well as examine the effects genes have on this critical time period.

Enrollment

350 estimated patients

Sex

All

Ages

20+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Aged greater than 20 years
  • Undergoing aortic valve surgery with or without CABG surgery
  • Receive and apical vent as part of the surgery

Exclusion criteria

  • Will not receive an apical left ventricular vent

Trial contacts and locations

1

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Central trial contact

Jochen D Muehlschlegel, MD, MMSc, MBA

Data sourced from clinicaltrials.gov

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