Transcriptional and Proteomic Analysis of Acute Kidney Injury (TPA-AKI)

University Hospital Muenster

Status: Not yet enrolling

Conditions: Acute Kidney Injury

Treatments: Other: No study-specific interventions

Study type: Observational

Funder types: Other

Identifiers

NCT06064305

AnIt22-03

Details and patient eligibility

About

Acute kidney injury is associated with worsened outcome for critically ill patients. Sepsis-associated and non-septic cardiothoracic surgery associated AKI have been reported, nonetheless, precise pathomechanistic differences as well as detectability of transcriptional and proteomic changes in correlation with imaging and plasma markers are unclear.

Full description

Acute kidney injury is a common and detrimental finding in critically ill/sepsis patients as well as non-septic patients post cardiothoracic surgery. In many cases renal replacement therapy is required and an acute kidney injury is linked to increased morbidity and mortality in intensive care patients. Using routinely obtained clinical samples as well as imaging data, this observational trial investigates the transcriptomic and proteomic determinants detectable in septic and non-septic AKI patient subsets and their correlation with outcome and AKI diagnostic parameters.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 150 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

• Inclusion criteria:

  • study consent;
  • KDIGO>=2;
  • vasoplegia and/or sepsis or elective nephrectomy.

• Exclusion criteria:

  • Age<18 years;
  • pregnancy/nursing;
  • preexisting CKD with eGFR<60m/min;
  • dialysis; former ogran transplantation;
  • HIV; hematologic malignancies;
  • immunsuppression;
  • 4h post biopsy non-pausable effective anticoagulation;
  • pre-existing coagulopathy

Trial design

60 participants in 3 patient groups

Septic AKI patients

Description:

Septic AKI patients

Treatment:

Other: No study-specific interventions

Non-septic post-cardiothoracic AKI patients

Description:

Non-septic post-cardiothoracic surgery AKI patients

Treatment:

Other: No study-specific interventions

non-AKI patients undergoing routine nephrectomy

Description:

non-AKI patients undergoing routine nephrectomy

Treatment:

Other: No study-specific interventions