Transcriptome Analysis of Human Bone Regeneration After Using an Anorganic Bovine Bone Graft With or Without a Combination of Polynucleotides and Hyaluronic Acid

University of Granada (UGR)

Status: Active, not recruiting

Conditions: Sinus Floor Augmentation

Treatments: Procedure: Maxillary sinus floor augmentation

Study type: Interventional

Funder types: Other

Identifiers

NCT06156488

0003-N-23

Details and patient eligibility

About

The goal of this clinical trial is to compare the expression of multiple genes related to bone regeneration in maxillary bone after being grafted with a commonly used biomaterial supplemented or not with a combination of hyaluronic acid and polynucleotides.

Enrollment: 5 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Partially edentulous patients.
• Kennedy class I in the upper jaw.
• Less than 5 mm of residual crestal bone to the maxillary sinus.
• Need for the replacement of teeth with dental implants.

Exclusion criteria

• Sinus pathology (sinusitis, mucocele, cysts).
• Smokers.
• Previous long-term (>3 months) use of drugs known to affect bone metabolism, such as bisphosphonates.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

5 participants in 2 patient groups

Anorganic bovine bone

Active Comparator group

Description:

Maxillary sinus floor augmentation grafted with anorganic bovine bone

Treatment:

Procedure: Maxillary sinus floor augmentation

Procedure: Maxillary sinus floor augmentation

Anorganic bovine bone + polynucleotides and hyaluronic acid

Experimental group

Description:

Maxillary sinus floor augmentation grafted with anorganic bovine bone + polynucleotides and hyaluronic acid

Treatment:

Procedure: Maxillary sinus floor augmentation

Procedure: Maxillary sinus floor augmentation