Transcriptome Profiling and Endometrial Receptivity

The Chinese University of Hong Kong

Status: Enrolling

Conditions: Pregnancy Related

Treatments: Procedure: endometrial biopsy and blood sampling

Study type: Observational

Funder types: Other

Identifiers

NCT03925311

2014.637

Details and patient eligibility

About

The aim of this study is to correlate and identify the biochemical markers which may reflect WOI. Blood samples will be collected and endometrial biopsy will be performed at particular time points.

Full description

Endometrial receptivity in the midluteal phase of the menstrual cycle, known as the window of implantation (WOI), occurs only for a very short period of time. However, so far, there is no reliable clinical and biochemical indicators of WOI. Therefore, this study is to correlate and identify the biochemical markers which may reflect WOI.

participants will be asked to be:

1. performed endometrial biopsy
2. taken blood for a few time points (e.g. pre-conception and being pregnant) and to compare different kinds of biochemical markers.

Enrollment: 220 estimated patients

Sex: Female

Ages: 20 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Age 20-40 years.

Exclusion criteria

• Uncorrected uterine anomalies, such as septate or bicornuate uterus, fibroids (submucous/intramural).
• Intrauterine adhesions.
• Adenomyosis.