TRanscriptomic Analysis of Circulating Endothelial Cells During Sepsis - TRACES Study

Assistance Publique - Hôpitaux de Paris

Status: Not yet enrolling

Conditions: Critical Illness With or Without Sepsis

Treatments: Other: Observational study

Study type: Observational

Funder types: Other

Identifiers

NCT04841824

APHP201060

Details and patient eligibility

About

Vascular dysfunction is an important mechanism involved in organ failure, in the setting of sepsis condition, with different types of circulating endothelial cells.Transcriptom analysis via RNAseq in different types of circulating endothelial cells, comapring critically ill patients with or without sepsis will allow determining differential gene expression for signal pathways in endothelial alteration and restoration associated with sepsis.

Enrollment: 1,000 estimated patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age between 18 and 85 years
• Admission in intensive care with or without sepsis
• Health insurance as per the national insurance system
• Informed and unopposed patient for participation (or referend closed one)

Exclusion criteria

• Patient under legal protection
• Patient under national medical help system
• Pregnancy

Trial design

1,000 participants in 2 patient groups

Critically ill patients with sepsis

Treatment:

Other: Observational study

Critically ill patients without sepsis