Transcriptomic Analysis of Incisional Hernia Based on High-throughput Sequencing Technology

Fudan University

Status: Completed

Conditions: Incisional Hernia; Extracellular Matrix Alteration

Treatments: Diagnostic Test: Transcriptomic analysis

Study type: Observational

Funder types: Other

Identifiers

NCT06366581

HD20240307

Details and patient eligibility

About

This study included patients who underwent surgical treatment for incisional hernia and non-hernia conditions. Surgical specimens were collected for transcriptome sequencing to obtain the gene expression list. Then genes analyzed by Gene Ontology, protein interactions, and signaling pathway enrichment using the expression matrix.

Enrollment: 36 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1.18 to 75 years 2.diagnosed with incisional hernia 3.normal tumour markers 4.elective surgery patients.

Exclusion criteria

1. patients with vital organ failure (heart liver, lung, kidney and others)
2. malignant tumors not been completely relieved by active treatment,
3. patients who have psychiatric diseases or comprehension disorders.
4. patients with metabolic disease involving connective tissue collagen.

Trial design

36 participants in 2 patient groups

IH group

Description:

Patients who underwent incisional hernia repair were defined as the experimental group (labelled as the IH group)

Treatment:

Diagnostic Test: Transcriptomic analysis

NC group

Description:

patients who underwent laparoscopic cholecystectomy were defined as the control group (labelled as the NC group)

Treatment:

Diagnostic Test: Transcriptomic analysis