Transcriptomic Study of Cutaneous Fibroblasts in Scleroderma (TRANSCLERO)

University Hospital Center (CHU) Dijon Bourgogne

Status

Enrolling

Conditions

Scleroderma

Treatments

Procedure: Skin samples

Other: Analysis of fibroblasts

Study type

Observational

Funder types

Other

Identifiers

NCT07256418

BONNOTTE 2025-2

Details and patient eligibility

About

Scleroderma is a complex connective tissue disease involving three interconnected pathophysiological axes: vascular hyperactivity and remodelling, immune system dysfunction and over-activation of fibroblasts at the origin of the fibrosis process in the skin and organs. Given that this pathology occurs preferentially in mature subjects, it is possible to suggest a potential inductive role for senescent fibroblasts, which would be responsible for activating and/or maintaining the immune response and systemic inflammation. Our hypothesis is that fibroblasts play a predominant role in the genesis and maintenance of this pathology.

Enrollment

60 estimated patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

FOR PATIENTS WITH SCLERODERMA :

Person who has given written consent
Person with systemic scleroderma

FOR CONTROL PARTICIPANTS :

Person who has given written consent
Person undergoing plastic, cosmetic and reconstructive surgery

Exclusion criteria

FOR PATIENTS WITH SCLERODERMA :

Person not affiliated to or not benefiting from a social security scheme
Person subject to a legal protection measure (curatorship, guardianship)
Person subject to a legal protection measure
An adult who is incapable or unable to give consent
Minors

FOR CONTROLLED PARTICIPANTS :

Person suffering from a chronic disease or under chronic treatment for autoimmune, inflammatory or dermatological diseases
Person not affiliated to or not benefiting from a social security scheme
Person under legal protection (curatorship, guardianship)
Person subject to a legal protection measure
An adult who is incapable or unable to give consent
Minors