Transcriptomic Study of IBD-associated Colorectal Cancer

Central Hospital, Nancy, France

Status: Completed

Conditions: Colorectal Cancer, Genetics of

Treatments: Genetic: transcriptomic analysis

Study type: Observational

Funder types: Other

Identifiers

NCT05060770

2021PI125

Details and patient eligibility

About

Chronic inflammatory bowel disease (IBD) is associated with an increased risk of colorectal cancer (CRC) in historical cohorts. The pathways of oncogenesis of these CRCs, which are very different clinically from de novo CRCs, are currently unknown. The aim of our work is to identify specific molecular signatures of CRC occurring in the setting of IBD.

Enrollment: 26 patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Person 18 years of age or older
• Person with colorectal cancer in the context of IBD
• Person who has received complete information on the organization of the research and who has signed an informed consent
• Person affiliated to a social security plan or beneficiary of such a plan.

Exclusion criteria

• Person referred to in articles L. 1121-5, L. 1121-7 and L1121-8 of the public health code:
• Pregnant woman, parturient or nursing mother
• Minor (not emancipated)
• Adult person subject to a legal protection measure (guardianship, curatorship, safeguard of justice)
• Person of legal age who is unable to express his or her consent
• Person deprived of liberty by a judicial or administrative decision, persons subject to psychiatric care under articles L. 3212-1 and L. 3213-1.