Transcutaneous Carbon Dioxide Pressure (tcPCO2) Monitoring for the Prediction of Extubation Failure in the ICU

V

Versailles Hospital

Status

Completed

Conditions

Ventilator Weaning

Treatments

Procedure: tcPCO2 measurement

Study type

Interventional

Funder types

Other

Identifiers

NCT02894177
P15/07_ tcPCO2

Details and patient eligibility

About

Difficult weaning from ventilation and extubation failure are major issues in intensive care, concerning 30% and 12% of patients respectively. These can be partly explained by the lack of accuracy of spontaneous breathing trial (SBT) failure criteria to predict extubation failure. The investigators performed a pilot study to evaluate transcutaneous carbon dioxide pressure (tcPCO2) monitoring during SBTs. The results showed that the difference between maximum and initial tcPCO2 (or ΔtcPCO2) was significantly higher in the group of patients who failed SBTs according to the usual criteria. Moreover, the results suggested that ΔtcPCO2 could be an accurate and early criterion for SBT failure. The size of the study could not examine ΔtcPCO2 regarding extubation failure. Therefore, the main objective of this study is to determine if Δ tcPCO2 during SBTs is associated with extubation failure.

Enrollment

130 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • > 18 years old,
  • ICU indicated
  • invasive mechanical ventilation via orotracheal or nasotracheal intubation
  • presence of criteria for initiation of the weaning process as stated on our ICU's protocol
  • resolution of the disease leading to mechanical ventilation

Exclusion criteria

  • mechanical ventilation during less than 24 hours

  • Tracheotomy and tracheostomy at ICU admission

  • Pregnancy

  • Patient under legal protection

    • Patient enrolled in another study regarding weaning or CO2 metabolism

Trial design

Primary purpose

Diagnostic

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

130 participants in 1 patient group

tcPCO2 measurement arm
Experimental group
Description:
Patients will be monitored by tcPCO2 during spontaneous breathing trials
Treatment:
Procedure: tcPCO2 measurement

Trial contacts and locations

1

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Central trial contact

Morisset Laure

Data sourced from clinicaltrials.gov

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