Transcutaneous pO2, Transcutaneous pCO2 and Central Venous SO2 Variations to Define Fluid Responsiveness

Chinese Academy of Medical Sciences & Peking Union Medical College

Status: Completed

Conditions: Hypotension; Shock; Fluid Challenge; Fluid Responsiveness

Treatments: Other: fluid challenge

Study type: Interventional

Funder types: Other

Identifiers

NCT01941472

MICU2013-1

Details and patient eligibility

About

Fluid challenge is often carried out in critical ill patients. Its responsiveness usually requires invasive monitoring. To use non-invasive methods is very tempting. Investigators hypothesize that transcutaneous pO2,transcutaneous pCO2 and Central Venous SO2 variations provide feasible estimation on fluid responsiveness in critical ill patients.

Enrollment: 40 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18 years and older ICU patients;
• Septic shock;
• Monitored with PICCO or Swan-Ganz catheter;
• The decision of fluid challenge made by the treating physician;

Exclusion criteria

• Evidence of fluid overload;
• Pregnancy

Trial design

Primary purpose: Screening

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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40 participants in 1 patient group

Septic shock

Experimental group

Description:

Adult patients (at least 18 years of age) with refractory hypotension secondary to sepsis who, at the discretion of treating physicians, required fluid challenge in the presence of invasive hemodynamic monitoring. Refractory hypotension was defined as need of vasopressors to maintain systolic blood pressure (SBP) no less than 90 mmHg despite adequate fluid resuscitation.

Treatment:

Other: fluid challenge