Transdiagnostic Cognitive Biomarkers

University of Minnesota (UMN)

Status: Enrolling

Conditions: Depression; Pain

Treatments: Behavioral: Health surveys online; Behavioral: Computer game/task

Study type: Interventional

Funder types: Other

Identifiers

NCT04864080

NEUR-2020-29420

Details and patient eligibility

About

The overall objective of this study is to determine the feasibility of identifying transdiagnostic biomarkers of cognitive function mediated by neuromodulation of the dorsolateral prefrontal cortex that are translatable across disease groups in order to more accurately phenotype clusters of cognitive dysfunction. Completing behavioral paradigms with electrophysiology and TMS is a challenging frontier. This study focuses on the feasibility of such an endeavor for those with chronic pain or depression as well as healthy controls.

Full description

This study aims to test the feasibility of procedures aimed at discovering transdiagnostic biomarkers for cognitive impairment in chronic pain and depression. Fifteen healthy control participants and 15 participants from each disease group (chronic pain, depression) will be recruited.

Using a task-based fmri, TMS will be targeted for priming of the Left DLPFC. EEG will be used during our behavioral paradigm to compare changes in DLPFC function before and after primed TMS.

Enrollment: 45 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Arm 1, healthy controls:

Inclusion Criteria:

• Have access to the online study platform.

Exclusion Criteria:

• under 18, non-English speaking

Arm 2: pain and depression:

Inclusion Criteria:

• Pain or depression

Exclusion Criteria:

• pregnant women

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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45 participants in 2 patient groups

Healthy Comparison Group

Active Comparator group

Description:

Behavioral tasks and surveys online.

Treatment:

Behavioral: Computer game/task

Behavioral: Health surveys online

Pain/Depression patients from clinic

Experimental group

Description:

MRI, TMS and EEG, and behavioral tasks and surveys online.

Treatment:

Behavioral: Computer game/task

Behavioral: Health surveys online