Transdiagnostic Treatment Personalization

Shannon E. Sauer-Zavala

Status: Completed

Conditions: Obsessive-Compulsive Disorder; Post Traumatic Stress Disorder; Anxiety Disorders; Depressive Disorder

Treatments: Behavioral: Standard UP Treatment; Behavioral: Capitalization UP Treatment; Behavioral: Compensation UP Treatment

Study type: Interventional

Funder types: Other

Identifiers

NCT04584879

53545

Details and patient eligibility

About

The primary purpose of this study is to explore whether the efficiency of treatment for anxiety and depressive disorders can be increased using two discrete strategies: personalized skill ordering and 2) treatment discontinuation based on proximal indicators of improvements. The present study will specifically use treatment components drawn from an evidence-based psychological intervention, the Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP). This intervention has strong empirical support for patients presenting with anxiety, depressive, and related disorders and contains therapeutic skills that are common in psychological interventions (e.g., psychoeducation, mindfulness training, cognitive restructuring, countering emotional avoidance, increasing interoceptive tolerance). This study will determine if prioritizing the order of treatment modules to capitalize on patient strengths or compensate for weakensses increases treatmen efficacy. Additionally, it will also identify under what conditions briefer treatment modules may be appropriate.

Enrollment: 72 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• diagnosis of at least one emotional disorder
• fluent in English
• medication stability

Exclusion criteria

• concurrent therapy
• psychological condition that would be better addressed by alternative treatments
• have received more than 5 sessions of cognitive behavioral therapy in the past 5 years

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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72 participants in 6 patient groups

Standard Group, Brief Intervention

Experimental group

Description:

Participants in this group will receive 6 sessions of treatment in accordance with the standard, published Unified Protocol (UP) manual.

Treatment:

Behavioral: Standard UP Treatment

Standard Group, Full Intervention

Experimental group

Description:

Participants in this group will receive 12 sessions of treatment in accordance with the standard, published Unified Protocol (UP) manual.

Treatment:

Behavioral: Standard UP Treatment

Capitalization Group, Brief Intervention

Experimental group

Description:

Participants in this group will receive 6 sessions of treatment organized to prioritize skills that capitalize on patient strengths.

Treatment:

Behavioral: Capitalization UP Treatment

Capitalization Group, Full Intervention

Experimental group

Description:

Participants in this group will receive 12 sessions of treatment organized to prioritize skills that capitalize on patient strengths.

Treatment:

Behavioral: Capitalization UP Treatment

Compensation Group, Brief Intervention

Experimental group

Description:

Participants in this group will receive 6 sessions of treatment organized to prioritize skills that compensate for patient weaknesses.

Treatment:

Behavioral: Compensation UP Treatment

Compensation Group, Full Intervention

Experimental group

Description:

Participants in this group will receive 12 sessions of treatment organized to prioritize skills that compensate for patient weaknesses.

Treatment:

Behavioral: Compensation UP Treatment