Transfer of Frozen Embryos in Natural Cycle: Evaluation of Impact of Spontaneous Versus HCG-triggered Ovulation on Pregnancy Rate (TECNAT)

Centre Hospitalier Universitaire de Nīmes

Status: Completed

Conditions: in Vitro Fertilization

Treatments: Other: HCG

Study type: Interventional

Funder types: Other

Identifiers

NCT03428165

2017-A02759-44 (Other Identifier)

NIMAO/2017-02/SH-01

Details and patient eligibility

About

The purpose of the study is to evaluated whether there is a difference in pregnancy rate when transferring frozen embryos between patietns having spontaneously ovulated versus those triggered to voulate with HCG.

Enrollment: 103 patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• The patient must have given their free and informed consent and signed the consent form
• The patient must be a member or beneficiary of a health insurance plan
• The patient is aged between 18 and 40
• Patient has regular cycles and classified as 'easy' for transfer of a frozen embryo at blastocyste stage (vitrification day 5)

Exclusion criteria

• The subject is participating in an interventional study, or is in a period of exclusion determined by a previous study
• The subject refuses to sign the consent
• It is impossible to give the subject informed information
• The patient is under safeguard of justice or state guardianship
• Patient using donated oocytes
• Necessity of pre-implantation diagnosis
• Patients with stage 3 or 4 endometriosis or adenomyosis

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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103 participants in 2 patient groups

human chorionic gonadotropin (HCG)

Other group

Description:

Ovulation triggered using HCG: choriogonadotropin alpha (Ovitrelle, Merck Serono), 250 μg/0.5ml

Treatment:

Other: HCG

spontaneous

No Intervention group