Transfer Strategy in an Oocyte Donation Programme

Institut Universitari Dexeus

Status: Terminated

Conditions: Embryo Transfer; Oocyte Donation; Infertility, Female

Treatments: Procedure: Cleavage-stage embryo transfer strategy; Procedure: Blastocyst-stage embryo transfer strategy

Study type: Interventional

Funder types: Other

Identifiers

NCT03088735

SMD-2017-03

Details and patient eligibility

About

It has been previously shown that although the activation of the embryonic genome can begin as early as two days of initiation of the embryonic development (D2), it is expressed on day 3 (D3). Without this activation, the embryo can not continue its development. Therefore, it has been suggested that extended culture to blastocyst stage could be an option to identify and better select embryos that have been able to carry out this activation. The purpose of this study is to compare cumulative pregnancy and live birth rates following transfer of cleavage embryos or blastocysts.

Enrollment: 134 patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients under their first or second cycle of a synchronous (fresh) oocyte donation cycle.

Exclusion criteria

• Preimplantation genetic screening or diagnosis cycles.
• Patients with strict blastocyst-stage embryo transfer indication by the couple's treating physician.

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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134 participants in 2 patient groups

Blastocyst-stage embryo transfer strategy

Experimental group

Treatment:

Procedure: Blastocyst-stage embryo transfer strategy

Cleavage-stage embryo transfer strategy

Active Comparator group

Treatment:

Procedure: Cleavage-stage embryo transfer strategy