Transformation of Somatosensory and Visual Coordinate Systems

Chang Gung Medical Foundation

Status: Unknown

Conditions: Stroke

Study type: Observational

Funder types: Other

Identifiers

NCT01177462

CMRPG590021G

Details and patient eligibility

About

Manipulation of object is a multisensory experience that includes tactile motion between the object and the fingerpad, visual motion elicited by the motion the object and the movement of the hand, and the active motor commend to control upper limb and hand conformation. It remains to be determined how such a complex interaction between touch and vision could be achieved effortlessly. In the present study, we will investigate how the motion information is transformed between touch and vision using the most novel approaches in human psychophysics, neuropsychology and monkey neurophysiology. Specifically, we will present tactile motion on primate fingerpads using a recently developed ball stimulator with a design in which we vary the direction of motion with respect to the skin surface and also vary the hand conformation and position. This setup allows us to systematically sample the possible scenarios involving coordinate transformation between the somatosensory and visual systems in conditions that could occur in hand exploration and object manipulation in daily life. We will present these tactile stimuli on normal human subject as well as stroke patients such as patients with spatial hemineglect. Finally, we will record from macaque monkeys in cortical areas that are thought to underlie the transformation of coordinates, such as the primary somatosensory cortex and posterior parietal cortex. The results of the present study will contribute to the understanding of multisensory integration and the rehabilitation for patients with impaired use of spatial information.

Enrollment: 90 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

For stoke patients

Inclusion Criteria:

• stroke patients
• stable medical condition
• can cooperate in evaluation

Exclusion Criteria:

• peripheral neuropathy
• limb ambulation

Trial design

90 participants in 3 patient groups

hemineglect stroke patients

Description:

Stroke patients with hemineglect

Control stroke patients

Description:

Stroke patients without hemineglect

Normal control

Description:

Normal subjects