Transfusion in Sickle Cell Disease: Screening of Sickle Cell Disease Trait in Blood Donors

Hanane EL KENZ

Status: Completed

Conditions: Sickle Cell Trait; Sickle Cell Disease

Treatments: Procedure: Blood sampling

Study type: Interventional

Funder types: Other

Identifiers

NCT03405688

CHUB-PRO-TRANSFU-DREPANO 2

Details and patient eligibility

About

Bearers of the sickle cell allele (S) are currently eligible for blood donations in Belgium. As blood donors are not tested for this allele, their heterozygous status is unknown. However, guidelines recommend to transfuse sickle cell patients with blood that is negative for the 'S' hemoglobin. To the investigator's knowledge, no study has been conducted to evaluate the impact of transfusion with blood originating from heterozygous donors on the transfusion performance and the improvement of clinical status of the sickle cell disease patients.

Enrollment: 173 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

All patients with sickle cell disease within the CHU Brugmann and the Queen Fabiola Children's Hospital (HUDERF)

Exclusion criteria

None

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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173 participants in 6 patient groups

Acute transfusion

Experimental group

Description:

Blood donor heterozygous for the sickle cell disease allele (HbAS genotype)

Treatment:

Procedure: Blood sampling

Control - Acute transfusion

Other group

Description:

Blood donor not bearer of the sickle cell disease allele (HbAA genotype)

Treatment:

Procedure: Blood sampling

Chronic transfusion

Experimental group

Description:

Blood donor heterozygous for the sickle cell disease allele (HbAS genotype)

Treatment:

Procedure: Blood sampling

Control - Chronic transfusion

Other group

Description:

Blood donor not bearer of the sickle cell disease allele (HbAA genotype)

Treatment:

Procedure: Blood sampling

Transfusion prior to surgery

Experimental group

Description:

Blood donor heterozygous for the sickle cell disease allele (HbAS genotype)

Treatment:

Procedure: Blood sampling

Control - Transfusion prior to surgery

Other group

Description:

Blood donor not bearer of the sickle cell disease allele (HbAA genotype)

Treatment:

Procedure: Blood sampling