Transgender In Transition (TRANSIT)

Universitätsklinikum Hamburg-Eppendorf

Status: Enrolling

Conditions: Gender Incongruence

Treatments: Diagnostic Test: Online surveys

Study type: Observational

Funder types: Other

Identifiers

NCT04028219

TRANSIT

Details and patient eligibility

About

Prospective trial in gender dysphoric patients who undergo gender-affirming hormone therapy, aiming to investigate psychological, biological and behavioural consequences of hormonal therapy.

Full description

Gender-affirming hormone treatment impacts myriads of body functions, from which it has to be assumed that only a minority has already been elucidated so far. This project aims to investigate the consequences and health-related outcomes of various hormone therapies in the treatment of gender dysphoric patients. The main scientific interest lies in the research of the effects of sex hormones on psychological, metabolic and behavioural parameters. For this purpose, various investigations are aimed at, including a clinical-diagnostic interview (external rating) and psychometric measurements in self-rating, behavioral experiments (e.g. in a virtual reality Elevated Plus Maze and the computer-based Ultimatum Game) and genetic investigation of the body's own materials (blood samples, stool samples, hair samples and saliva samples). The results of this study should form the basis to better understand consequences of the long-term administration of sex hormones.

Enrollment: 750 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• diagnosis of gender incongruence (ICD-11) or gender dysphoria (DSM-5)
• written informed consent following adequate oral and written Information
• before gender-affirming hormonal treatment

Exclusion criteria

• pregnancy or breast-feeding

Trial design

750 participants in 1 patient group

Transgender patients

Description:

Gender dysphoric patients undergoing hormone treatment

Treatment:

Diagnostic Test: Online surveys