Transient Receptor Potential Vanilloid One (TRPV1) Receptor Expression in Children With Retrosternal Pain

Medical College of Wisconsin

Status: Completed

Conditions: Esophagitis; Gastrointestinal Symptoms; Retrosternal Pain; Epigastric Pain

Study type: Observational

Funder types: Other

Identifiers

NCT00677378

CHW 06/34

Details and patient eligibility

About

We would like to evaluate the changes in nerve innervation and TRPV1 receptor expression along with microscopic changes associated with heart burn and abdominal pain

Full description

Approximately 5% of children between 10-17 years of age report symptoms of heart burn, epigastric pain or regurgitation. This study will evaluate the changes in nerve innervation and TRPV1 receptor expression in children having upper endoscopy for evaluation of heart burn and abdominal pain.

Enrollment: 77 patients

Sex: All

Ages: 5 to 17 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Retrosternal and/or epigastric pain and esophagitis
• Retrosternal and/or epigastric pain but no macroscopic or microscopic esophagitis
• Gastrointestinal symptoms such as diarrhea, regurgitation, rumination, vomiting, feeding aversion, non-organic failure to thrive, celiac disease with no macroscopic or microscopic esophageal inflammation

Trial design

77 participants in 2 patient groups

EXPERIMENTAL

Description:

Children undergoing an endoscopy for retrosternal chest pain, epigastric pain, regurgitation, heart burn or dyspepsia.

CONTROL

Description:

Children undergoing an endoscopy for reasons not stated in the experimental group condition (i.e. celiac disease, rectal bleeding, polyps, weight loss, malabsorption).