Transition to Propofol After Sevoflurane Anaesthesia to Prevent Emergence Agitation

Assiut University

Status and phase: Completed; Phase 4

Conditions: Emergence Agitation

Treatments: Drug: Normal saline; Drug: Propofol

Study type: Interventional

Funder types: Other

Identifiers

NCT03179293

propofol after sevo

Details and patient eligibility

About

The aim of this randomized double-blinded study is to determine whether transition to propofol for 3 min at the end of sevoflurane anaesthesia reduces the incidence of EA in children undergoing genito-urinary paediatric surgeries.

Enrollment: 70 patients

Sex: All

Ages: 3 to 8 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Children Aged 3 - 8 years
2. ASA (I - II)
3. Genito-urinary Surgeries: hernia, varicocele, etc.

Exclusion criteria

1. Patients or parental refusal
2. Allergy to Propofol or egg products; or a family history of malignant hyperthermia
3. Operating time more than 60 minutes
4. Performance of any other procedure under the same anaesthetic
5. Presence of co-morbidities or congenital anomalies
6. mental disease, neurologic disease, treatment with sedatives, full stomach, or indication for rapid sequence induction.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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70 participants in 2 patient groups, including a placebo group

Propofol

Active Comparator group

Description:

propofol 1 mg/kg IV bolus will be given to the patient with a further 2 mg/kg administered manually over the next 3 min prior to the patient leaving the OR

Treatment:

Drug: Propofol

Control

Placebo Comparator group

Description:

Normal saline will be administered IV over the next 3 min prior to the patient leaving the OR

Treatment:

Drug: Normal saline