Translational Assessment of Vitiligo According to Body Locations (Vitiligo BL)

Centre Hospitalier Universitaire de Nice

Status

Active, not recruiting

Conditions

Vitiligo

Treatments

Other: Biopsy for the patient group

Other: biopsy for the volunteer group

Study type

Interventional

Funder types

Other

Identifiers

NCT06068218

23-PP-06

Details and patient eligibility

About

Vitiligo affects 0.5 to 2% of worldwide population and has a demonstrated impact on the quality of life.

Optimal treatment of vitiligo requires to target the auto-immune inflammatory response (to halt the depigmentation process), but also to induce the differentiation of melanocyte stem cells (to induce repigmentation). There is a well demonstrated discrepancy in the repigmentation response between anatomical areas of the body. Face and neck are the best responder with complete or almost complete repigmentation achieved in most cases under treatment. Trunk and limbs could have a complete or almost complete repigmentation in approximately half of the cases. The repigmentation is much more difficult in wrists, elbows, knees, proximal part of the hands. Finally, some areas such as the extremities of hands and feet, palms, soles, are almost impossible to repigment.

The investigator hypothesize that there are some factors that are produced in the skin that prevent (or at least decrease) the differentiation but also probably the migration and proliferation of melanocytes.

Primary objective To compare the mRNA expression of each types of cells in the skin of vitiligo patients compared to healthy volunteers according to body locations

Enrollment

20 patients

Sex

All

Ages

18 to 70 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Men and women with non-segmental vitiligo for the vitiligo group and men and women without any auto-immune disorder for the control group
≥ 18 and <70 years
For women of child-bearing age, a urine pregnancy test (βHCG in urines) will be performed.
Affiliation to a social security system
Signed informed consent

Exclusion criteria

Pregnant women
Segmental or mixed vitiligo
Vitiligo with less than 2 years duration
Skin auto-immune or inflammatory skin disorders other than vitiligo (ie. active atopic dermatitis, psoriasis, lichen planus…)
Exposure to sun (with intent to tan or repigment the skin) or artificial UV (UV cabins, lamps or lasers) during the month before inclusion
Concomitant use of topical or systemic immunosuppressive medication or steroids
Contra-indication to xylocaine with 2 % adrenalin
Pregnant or breast-feeding women
Vulnerable people: minors, adult under guardianship or deprived of freedom, adult under curatorship
Participants in other clinical therapeutic studies involving a drug that could interfere with the present evaluation