Transplantation of Autologous RPE Versus Translocation of Autologous RPE and Choroid in AMD

The Ludwig Boltzmann Institute of Retinology and Biomicroscopic Laser Surgery

Status: Completed

Conditions: Age-Related Macular Degeneration

Treatments: Procedure: Transplantation of autologous RPE; Procedure: Translocation of autologous RPE and Choroid

Study type: Interventional

Funder types: Other

Identifiers

NCT00401713

FR-01-CI-2006

Details and patient eligibility

About

The purpose of this study is to evaluate two surgical interventions in patients with AMD.

Full description

The Submacular surgical trials have shown that submacular membrane extraction alone did not improve or preserve visual acuity in patients with AMD. Transplantation of autologous RPE and translocation of autologous RPE and choroid represent two promising therapeutic interventions in patients with AMD. This prospective, randomized clinical trial compares the two surgical treatments and additionally compares the clinical results (visual acuity, FLA) with OCT- and UHR-OCT data.

Enrollment: 40 estimated patients

Sex: All

Ages: 50+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• AMD and submacular cnv
• non responders to laser treatment or pdt
• treatment: rpe transplantation or rpe + choroid translocation
• age over 50 years

Exclusion criteria

• other additional retinal diseases, like diabetic or hypertensive retinopathy and vascular diseases.
• optic atrophy
• unstable glaucoma

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)