Transplantation of Frozen Thawed Ovarian Tissue High Reproductive Performance

Sheba Medical Center

Status and phase: Completed; Phase 3

Conditions: Reproductive Performance Following Ovarian Transplantation

Treatments: Procedure: transplantation of ovarian tissue

Study type: Interventional

Funder types: Other

Identifiers

NCT02659592

SHEBA-03-3026-DM-CTIL

Details and patient eligibility

About

Design: prospective cohort study. Setting: Tertiary university-affiliated ART and oncology centers. Patients: 20 cancer survivors who underwent ovarian transplantation of frozen-thawed ovarian tissue, with the aim to conceive.

Interventions: Ovarian tissue cryopreservation (OTCP) and transplantation, endocrine monitoring, IVF.

Full description

Main Outcomes expected:

Endocrine profile IVF results, pregnancy rates following transplantation of ovarian tissue live-births rates following transplantation of ovarian tissue cancer disease recurrence

Enrollment: 20 patients

Sex: Female

Ages: 20 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria: infertile patients who stored ovarian tissue to preserve fertility prior to potentially sterilizing cancer treatments

Exclusion Criteria:

• active disease, fertile patients post cancer treatment

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

infertile cancer survivors

Experimental group

Description:

infertile cancer survivors who seek to conceive and had frozen ovarian tissue when diagnosed years before

Treatment:

Procedure: transplantation of ovarian tissue