Transpulmonary Pressure in Right Ventricle Protection of ARDS

Capital Medical University

Status: Enrolling

Conditions: Acute Cor Pulmonale; Acute Respiratory Distress Syndrome

Treatments: Procedure: mechanical ventilation strategy guided by transpulmonary pressure

Study type: Interventional

Funder types: Other

Identifiers

NCT05629832

Ptp right ventricle protection

Details and patient eligibility

About

To compare the effect between mechanical ventilation strategy guided by transpulmonary pressure and tranditional lung protective ventilation strategy in acute respiratory distress syndrome for right ventricle protection.

Enrollment: 40 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• duration of invasive mechanical ventilation less than 72 hours;
• meet the diagnostic criteria of Berlin definition for ARDS;
• age older than 18

Exclusion criteria

• esophageal surgery or damage;
• cardiac surgery;
• severe bronchopleural fistula;
• serious arrhythmia; pneumothorax;
• tricuspid stenosis;
• heparin allergy;
• chronic pulmonary heart disease

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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40 participants in 2 patient groups

PTP group

Experimental group

Treatment:

Procedure: mechanical ventilation strategy guided by transpulmonary pressure

Control group

No Intervention group