Transpulmonary Pressure Measurements in Intubated Children With Covid-19 Respiratory Failure

Mayo Clinic

Status: Withdrawn

Conditions: COVID 19

Treatments: Diagnostic Test: Transpulmonary pressure measurements

Study type: Interventional

Funder types: Other

Identifiers

NCT04519411

20-003743

Details and patient eligibility

About

The purpose of this study is to gather information to help doctors understand how Covid-19 affects the lungs in children.

Sex: All

Ages: Under 17 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients 0-17 years of age, 10 kg or greater, with suspected or confirmed Covid-19 respiratory failure requiring endotracheal intubation and mechanical ventilation admitted to Mayo Clinic Hospital, St. Mary's Campus Pediatric Intensive Care Unit.

Exclusion criteria

• Patients <10 kg
• Patients with pre-existing chronic mechanical ventilation (chronic respiratory failure)
• Patients with known esophageal disease (strictures, known esophageal anatomic abnormalities)
• Patients with severe coagulopathy (for which placement of esophageal balloon or other gastric tube via nose or mouth is contraindicated)
• Patients who are pregnant (as determined by standard pregnancy testing criteria for Pediatric ICU admission).

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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0 participants in 1 patient group

Intubated pediatric patients with COVID-19 respiratory failure

Experimental group

Treatment:

Diagnostic Test: Transpulmonary pressure measurements