Transthoracic Echocardiography of Ventricular Function of Parturients in Labor

Dartmouth Health

Status: Completed

Conditions: Obstetric Labor Complications; Cardiovascular Risk Factor; Cardiovascular Diseases in Pregnancy

Study type: Observational

Funder types: Other

Identifiers

NCT04481503

D20144

Details and patient eligibility

About

This echocardiography study will characterize heart structure and function during labor. Imaging of the heart during the stress of labor could increase detection of subclinical cardiovascular disease using advanced imaging techniques. Cardiac serum biomarkers and complication rates will also be measured and compared between patients with and without evidence of cardiovascular disease on echocardiography.

Enrollment: 150 patients

Sex: Female

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• All healthy parturients 18 years of age or older with estimated gestation greater than or equal to 37 weeks who are expected to deliver during their hospitalization.
• During the echocardiographic exam, the patient must be in active labor with cervical dilation between 6-10 cm and contractions that are spaced less than 5 minutes apart.

Exclusion criteria

• Known functional or structural heart disease
• Previously diagnosed pulmonary hypertension.
• Comorbid disease other than diet controlled gestational diabetes, uncomplicated obesity, mild asthma and euthyroid patients with a history of hypo or hyperthyroidism.
• Parturients endorsing active use of non-prescription mind-altering drugs including cocaine, methamphetamine, or ketamine.
• Other non-inclusion criteria include inability to tolerate left lateral positioning either symptomatically or by fetal heart rate monitoring, suspected hypo-or hypercoagulable states that was not previously diagnosed, hemodynamic instability requiring >2 L crystalloid administration within 1 hour time frame after epidural placement or vasopressor administration of >15 mg ephedrine or >300 mcg phenylephrine administration within 1 hour after epidural placement.