Transversalis Fascia Plane Block Versus Intrathecal Dexmedetomidine in Patients Undergoing Cesarean Section

Tanta University

Status: Enrolling

Conditions: Cesarean Section; Intrathecal Dexmedetomidine; Transversalis Fascia Plane Block

Treatments: Other: Transversalis fascia plane block; Drug: Intrathecal dexmedetomidine

Study type: Interventional

Funder types: Other

Identifiers

NCT07170267

36264PR1335/8/25

Details and patient eligibility

About

This study aims to compare the analgesic efficacy of the transversalis fascia plane (TFP) block and intrathecal dexmedetomidine in patients undergoing cesarean section (CS).

Full description

Cesarean section (CS) is a commonly performed major surgical procedure that results in substantial postoperative pain and patient dissatisfaction.

Spinal anesthesia is commonly used in CS surgery. However, it may be associated with several side effects, particularly hypotension.

Dexmedetomidine is an α2 adrenergic receptor agonist that has an analgesic effect.

Ultrasound-guided interfascial plane blocks are often used in multimodal analgesia regimens. Local anaesthetic injection into the transversalis fascia plane (TFP) anesthetizes the proximal branches of T12 and L1 which targeted in the plane between the transversus abdominis muscle and the transversalis fascia.

Enrollment: 50 estimated patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age from 18 to 40 years.
• American Society of Anesthesiology (ASA) physical status II.
• Women undergoing cesarean section under spinal anesthesia.

Exclusion criteria

• Contraindication to spinal anesthesia.
• Women with body mass index >40 kg/m2.
• Pregnancy-induced hypertension
• Local infection at the site of injection.
• Known cardiovascular disease
• Coagulation abnormality.
• History of chronic pain.
• Abuse of drugs or alcohol.
• History of allergies to any study medications.
• Seizure disorders.
• Any pregnancy complications requiring conversion to general anesthesia.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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50 participants in 2 patient groups

TFP group

Experimental group

Description:

Patients will receive spinal anesthesia (using 2.5 mL of hyperbaric bupivacaine 0.5%) with bilateral transversalis fascia plane (TFP) block (using 20 mL of bupivacaine 0.25%) at the end of surgery.

Treatment:

Other: Transversalis fascia plane block

Control group

Active Comparator group

Description:

Patients will receive spinal anesthesia (using 2.5 mL of hyperbaric bupivacaine 0.5%) + (5 µg intrathecal dexmedetomidine diluted in 0.5ml saline) with a sham block at the end of surgery.

Treatment:

Drug: Intrathecal dexmedetomidine