Transversus Abdominis Plane Block for Postoperative Analgesia in Living Donor Hepatectomy

Inonu University

Status and phase: Completed; Phase 4

Conditions: Acute Pain

Treatments: Drug: Transversus Abdominis Plane Block; Drug: standard general anesthesia

Study type: Interventional

Funder types: Other

Identifiers

NCT02645903

TAP

Details and patient eligibility

About

Living donor organ transplantation has increased in recent years due to an increased need for organs. The objective of this study was to investigate the effects of a TAP block on postoperative analgesia and opioid consumption in liver transplantation donors in whom a right lateral extending upper mid-line abdominal incision was used.

Full description

This prospective randomized controlled double-blinded study was conducted with 50 liver transplantation donors between 18-65 years who were scheduled to undergo right hepatectomy surgery. Cases to whom TAP block with ultrasound was applied after standard general anesthesia were determined as Group 1 and cases to whom only standard general anesthesia was applied, were determined as Group 2.

Enrollment: 50 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Liver transplantation donors

Exclusion criteria

• Patients with a history of allergy to the drugs used in the study protocol, coagulation pathology, opioid tolerance

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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50 participants in 2 patient groups, including a placebo group

transversus abdominis plane block

Active Comparator group

Description:

Patients who received a tranversus abdominis plane block with ultrasound after standard general anesthesia represented Group 1. The tranversus abdominis plane block was performed bilaterally by obtaining an image with real time ultrasound guidance with a 6-13 MHz linear probe. The block was placed with a 22 G 80 mm needle while obtaining real-time images via an in-plane technique. Two 20 mL syringes were prepared after preparing a local anesthetic concentration of 1.5 mg/kg of 0.5% bupivacaine to 40 mL with saline. These were administered to the left and right abdominal walls. Postoperative analgesia was administered through a morphine the patient-controlled analgesia device.

Treatment:

Drug: Transversus Abdominis Plane Block

nonblocked

Placebo Comparator group

Description:

Patients who received standard general anesthesia alone made up Group 2. Postoperative analgesia was administered through a morphine the patient-controlled analgesia device.

Treatment:

Drug: standard general anesthesia