Transversus Abdominis Plane Block Versus Local Anesthetic Infiltration for Pain Control in the Abdominal Surgery (TAP)

Taipei Medical University

Status: Completed

Conditions: Postoperative Pain

Treatments: Procedure: Patient controlled analgesia; Procedure: local infiltration; Procedure: transversus abdominis plane block

Study type: Interventional

Funder types: Other

Identifiers

NCT02029755

201309028

Details and patient eligibility

About

Postoperative analgesia is an important part of the anesthetic care. According to the recent studies, multimodal analgesia can provide better analgesia & patient satisfaction with fewer side effect. For example, combining intravenous, intramuscular or oral analgesics with transversus abdominis plane (TAP) block or local anesthetic (LA) infiltration as the multimodal analgesia, can furnish a more effective pain control after the abdominal surgery.

For abdominal surgery, both local infiltration and TAP block target on relieving somatic pain. Local anesthetic wound infiltration is easy to perform with low risk. As the advancement of ultrasound technology, performing the TAP block also becomes easier, safer and more accurate. But whether LA infiltration or TAP block is better for the multimodal analgesia regimen remains unclear.

This study is to compare the postoperative pain score, opioid consumption, side effects, and quality of recovery between these two analgesic methods in patients undergoing abdominal surgery. The investigators hypothesized that TAP block may be more effective than LA infiltration as a part of the multimodal analgesia, and can improve the recovery after the abdominal surgery.

Enrollment: 108 patients

Sex: All

Ages: 20 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult (20~65y/o)
• American Society of Anesthesiologists (ASA) physical status I~II
• Patients scheduled for regular abdominal surgery under general anesthesia

Exclusion criteria

• ASA physical status ≥ 3
• Allergy to morphine or local anesthetics
• Morphine tolerance
• Drug abuse or addiction
• Bleeding tendency

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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108 participants in 3 patient groups

TAP block

Experimental group

Description:

postoperative analgesia with sono-guided transversus abdominis plane block and intravenous patient controlled analgesia (IV-PCA). Bilateral sono-guided TAP block will be performed after the induction of general anesthesia. 20 ml of 0.25% ropivacaine will be injected to the transversus abdominis plane under ultrasound guidance at each side (total 40 ml). IV-PCA with morphine will be ready for postoperative pain control at the end of the surgery.

Treatment:

Procedure: Patient controlled analgesia

Procedure: transversus abdominis plane block

Local infiltration

Active Comparator group

Description:

postoperative analgesia with local anesthetics infiltration at surgical wound and intravenous patient controlled analgesia (IV-PCA). 20 ml of 0.5% ropivacaine will be injected at the surgical wound by the surgeon before the closure of wound. IV-PCA with morphine will be ready for postoperative pain control at the end of the surgery.

Treatment:

Procedure: Patient controlled analgesia

Procedure: local infiltration

PCA only

Active Comparator group

Description:

postoperative analgesia with intravenous patient controlled analgesia. IV-PCA with morphine will be ready for postoperative pain control at the end of the surgery.

Treatment:

Procedure: Patient controlled analgesia