Transversus Thoracic Plane Block for Perioperative Analgesia in Cardiac Surgery

Saint-Joseph University

Status: Not yet enrolling

Conditions: Cardiac Surgery; Transversus Thoracic Plane Block; Post Operative Pain

Treatments: Procedure: Transversus Thoracic Plane Block

Study type: Interventional

Funder types: Other

Identifiers

NCT06546722

CEHDF2392

Details and patient eligibility

About

The goal of this clinical trial is to learn if perioperative Transversus Thoracic Plane Block (TTPB) decrease perioperative pain after cardiac surgery. The main questions it aims to answer are:

1. does Transversus Thoracic Plane Block decrease perioperative pain after cardiac surgery more than the standard analgesic treatment?
2. Are the results different if the investigators perform Transversus Thoracic Plane Block before surgery or at the end of surgery?

Enrollment: 150 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All patients scheduled for cardiac surgery via sternotomy under cardiopulmonary bypass

Exclusion criteria

• Previous cardiac surgery
• Urgent surgery
• Pregnant women
• Allergy to local anesthetics
• Opioid dependence
• Low ejection fraction < 30%
• Presence or onset of cognitive or neurological disorders preventing pain assessment
• Infection at injection sites
• Coagulopathy
• Patients on dual antiplatelet therapy
• Renal insufficiency with Glomerular filtration rate (GFR) < 30 mL/min
• History of thoracic radiotherapy
• History of mastectomy

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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150 participants in 3 patient groups

Placebo

No Intervention group

Description:

This group receives standard analgesic treatment and no Transversus Thoracic Plane Block is performed

Transversus Thoracic Plane Block pre

Active Comparator group

Description:

This group receives standard analgesic treatment and Transversus Thoracic Plane Block is performed before surgery

Treatment:

Procedure: Transversus Thoracic Plane Block

Transversus Thoracic Plane Block post

Active Comparator group

Description:

This group receives standard analgesic treatment and Transversus Thoracic Plane Block is performed at the end of surgery

Treatment:

Procedure: Transversus Thoracic Plane Block