Trastuzumab Emtansine(T-DM1) After Trastuzumab Deruxtecan(T-DXd) in HER2-Positive Breast Cancer in Korea

Seoul National University

Status: Enrolling

Conditions: Cancer of Breast; Trastuzumab Deruxtecan; Trastuzumab Emtansine

Study type: Observational

Funder types: Other

Identifiers

NCT06928818

H-2412-069-1597

Details and patient eligibility

About

Prospective observational study of trastuzumab emtansine immediately after trastuzumab deruxtecan in patients with advanced HER2-positive breast cancer in Korea

Enrollment: 100 estimated patients

Sex: All

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• HER2-positive, advanced (unresectable locally advanced or metastatic) breast cancer
• Prior treatment with trastuzumab deruxtecan(T-DXd) in the advanced setting
• Intention to treat with Trastuzumab Emtansine (T-DM1) as first therapy upon T-DXd progression

Exclusion criteria

• Any systemic treatment, other than T-DM1, for breast cancer after trastuzumab deruxtecan (As an exception, patients treated with endocrine agents, not in combination with cytotoxics or antibody-drug conjugates, will be permitted in the study)

• Has been previously treated with T-DM1 for advanced breast cancer

• Has been previously treated with 4 or more lines of therapy for advanced breast cancer

  • Half (50%) or more patients will be those who were treated with second-line trastuzumab deruxtecan (i.e. patients at the later line will be capped).