Trauma as a Trigger for Autoimmunity (TATA)
Status
Conditions
Treatments
Details and patient eligibility
About
To analyse the immunological reaction to Trauma (pertrochanteric femoral fracture with consequent osteosynthesis) in the first weeks up to one year postoperatively with focus on the development of autoimmunity.
Full description
This project represents a unique study of the influence of trauma on the immune system. It addresses the question whether an excess of apoptotic/necrotic cells can induce an at least transient autoimmune phenomena in humans. If the hypothesis of a transient induction of autoimmunity by trauma proves to be correct, this study will provide a novel insight into the pathogenesis of autoimmune diseases.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- pertrochanteric femoral fracture (≤7 days)
- planned gamma nail osteosynthesis
- ability to give written informed consent
Exclusion criteria
- Severe hepatic and renal failure
- current active oncological disease
- current immunosuppressive or biological therapy
- known systemic autoimmune disease
- foreseeable lack of complete follow-up (e.g. due to generally poor health)
- cognitive impairment (delirium, dementia, alteration of consciousness)
- insufficient knowledge of project language
- pregnancy
Trial contacts and locations
Loading...
Data sourced from clinicaltrials.gov
Clinical trials
Research sites
Resources
Legal