Treat Clozapine ( CLZ )-Resistant Schizophrenia Comparing CLZ + Haloperidol vs. CLZ + Electroconvulsive Therapy (ECT) (TCRS)

Khon Kaen University

Status: Completed

Conditions: Schizophrenia

Treatments: Drug: clozapine+haloperidol; Drug: clozapine,electroconvulsive therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT00753051

HE501122

Details and patient eligibility

About

Clozapine treatment resistant schizophrenia is still prevalent.The effectiveness of augmenting clozapine : one augmenting with haloperidol and the other with electroconvulsive therapy should be determined.This study is a randomized control trial.

Enrollment: 18 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. schizophrenic patients diagnosed with schedules for clinical assessment in neuropsychiatry ( SCAN )in accordance with DSM-IV-TR or ICD-10
2. Resistant to at least 6 weeks of clozapine treatment in therapeutic dosage
3. Voluntary to participate the research protocol expressed by signing informed consent form

Exclusion criteria

1. Patient does not volunteer himself or herself
2. Patient is having epilepsy, DM, cardiac disease, autistic disorder and illiterate
3. Patient is deaf, blind , dumb to obstruct good communication

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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18 participants in 2 patient groups

1.

Active Comparator group

Description:

clozapine as the main agent and it will be adjuncted by haloperidol

Treatment:

Drug: clozapine+haloperidol

2.

Active Comparator group

Description:

clozapine as the main agent and it will be adjuncted by electroconvulsive therapy

Treatment:

Drug: clozapine,electroconvulsive therapy