Treating Alcohol Use In Older Adults With Depression

US Department of Veterans Affairs (VA)

Status and phase: Completed; Phase 4

Conditions: Alcoholism; Depression

Treatments: Drug: Placebo; Drug: NALTREXONE

Study type: Interventional

Funder types: Other U.S. Federal agency

Identifiers

NCT00018824

MHBS-009-98S

Details and patient eligibility

About

The purpose of this study is to test the efficacy combining a treatment for depression with a treatment for alcohol dependence.

Full description

This study aims to study 80 patients with comorbid alcohol dependence and a depressive syndrome. After appropriate detoxification, patients are started on either naltrexone 50 mg or placebo. After one week, sertraline is added in an open label fashion. It is hypothesized that those patients receiving combination therapy will last 3 months with follow-up tracking lasting 1 year.

Enrollment: 74 patients

Sex: All

Ages: 55+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Age > 55
• Current depressive syndrome
• Current alcohol dependence
• No psychosis
• No opioid or cocaine abuse or dependence

Exclusion Criteria:

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Triple Blind

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74 participants in 2 patient groups, including a placebo group

1

Experimental group

Description:

Naltrexone

Treatment:

Drug: NALTREXONE

2

Placebo Comparator group

Description:

Placebo

Treatment:

Drug: Placebo