Treating Intraoperative Bradycardia in Non-cardiac Surgery Patients With Atropine at Heart Rates Below 60 Versus 30 Beats Per Minute and Norepinephrine Requirements (RAPID)

University of Hamburg-Eppendorf

Status

Enrolling

Conditions

Intraoperative Bradycardia

Treatments

Drug: Giving atropine at heart rates below 30 beats per minute

Drug: Giving atropine at heart rates below 60 beats per minute

Study type

Interventional

Funder types

Other

Identifiers

NCT06922097

2025-101426-BO-ff

Details and patient eligibility

About

The RAPID trial is a randomized, single-center trial investigating whether giving atropine at heart rates below 60 beats per minute versus giving atropine only at heart rates below 30 beats per minute reduces the amount of norepinephrine needed to keep MAP above 65 mmHg in non-cardiac surgery patients with intraoperative bradycardia.

Enrollment

186 estimated patients

Sex

All

Ages

50+ years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria: Consenting patients ≥50 years scheduled for elective non-cardiac surgery with general anesthesia that is expected to last ≥60 minutes with at least two of the following risk criteria for developing acute kidney injury:

Age ≥65 years
American Society of Anesthesiologists physical status III or IV
Chronic arterial hypertension
Diabetes mellitus requiring medication
Intraabdominal surgery
Preoperative renal insufficiency (serum creatinine ≥1.2 mg/dL)

Exclusion Criteria:

Patients with the following exclusion criteria: contraindication for atropine administration (e.g., myasthenia gravis, high-grade aortic stenosis, high-grade coronary artery disease, glaucoma, paralytic ileus, prostatic hypertrophy); renal replacement therapy within the previous 3 months; chronic kidney disease with an estimated glomerular filtration rate <20 mL/min/1.73 m2; pregnancy.