Treatment Effects Inclusive Cognitive Impact and Possibilities to Individually Adjusted Treatment in Patients With Intracranial Tumors With Clinical, Neuropsychological and Imaging Parameters

Lund University Hospital

Status: Completed

Conditions: Intracranial Tumor

Treatments: Other: MRI, neuropsychological evaluation, blood sampling

Study type: Interventional

Funder types: Other

Identifiers

NCT01674582

Version1.0

Details and patient eligibility

About

The main purposes with this trial is to investigate the potential of MRI with diffusion and blood volume, flow in brain to diagnose and to measure treatment effects in patients with intracranial tumors, especially gliomas and metastases in a prospective trial, to evaluate the possibilities to individually adjusted treatment in this category of patients depending on treatment outcomes measured by MRI, to perform clinical follow up in connection with MRI to evaluate a correlation and to perform testing of cognitive ability before, during, and after treatment and to investigate if given treatment causes any decrease in the patients habitual state.

Enrollment: 150 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 18 years or older
• Suspected primary brain tumor, verified glioblastoma or non surgically treated metastases from solid tumor
• Increasing MRI changes in patients with previous verified glioblastoma
• Be able to speak Swedish without difficulties (because of the neuropsychological investigations)
• Written informed concent

Exclusion criteria

• Unability to perform MRI

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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150 participants in 1 patient group

MRI, Neuropsychological testing

Other group

Treatment:

Other: MRI, neuropsychological evaluation, blood sampling