Treatment for Acute Spinal Cord Injury

Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan

Status and phase

Terminated

Phase 2

Phase 1

Conditions

Spinal Cord Injury

Treatments

Procedure: Transplantation of bone marrow stromal cell

Study type

Interventional

Funder types

Other

Identifiers

NCT00695149

UHA_SCI0401

Details and patient eligibility

About

This clinical trial aims to treat a damaged spinal cord by injecting your own bone marrow stromal cells (autologous bone marrow stromal cells) into cerebrospinal fluid through the lumbar puncture, and assess the safety and efficacy of the procedure.

Enrollment

5 patients

Sex

All

Ages

15 to 60 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Spinal cord injury is confirmed with MRI
Methylprednisolone therapy according to this study can be started within 8 hours after the injury
Bone marrow stromal cells (BMSCs) incubation can be started within 72 hours after the injury
Age between 15 and 60
With the informed consent of obtaining bone marrow and injecting incubated BMSCs.

Exclusion criteria

Complete disruption of spinal cord
Central spinal cord injury
Spinal canal stenosis before the injury
Brain or spinal cord disease before the injury
Positive serologic test in at least one of the following; HBs antigen, HCV antibody, HIV antibody, or HTLV-1 antibody
Pregnancy