Treatment of a Cancerous Disease of the Peritoneum With Complete Cytoreductive Surgery and Intraperitoneal Chemohyperthermia

Gustave Roussy

Status and phase

Terminated

Phase 2

Conditions

Endocrine Tumors

Colon Tumors

Peritoneum Tumors

Appendix Tumors

Rectum Tumors

Treatments

Drug: Oxaliplatin and irinotecan

Study type

Interventional

Funder types

Other

Identifiers

NCT00180960

CHIP4 Phase II

Details and patient eligibility

About

The purpose of this study is to evaluate the treatment of a cancerous disease of the peritoneum with complete cytoreductive surgery with intraperitoneal chemohyperthermia using oxaliplatin plus irinotecan.

This is a Phase II study with 100 patients. Origins of the tumors: these include colon, rectum, appendix, peritoneum, and endocrine tumors.

Sex

All

Ages

18 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Peritoneal seedings coming from colon, rectum, pseudomyxoma (appendix), peritoneum (mesothelioma and serous tumors), or endocrine tumors.
No extra-abdominal metastases
Good general status (American Society of Anesthesiologists Physical Status score [ASA] 1 or 2)
Signed consent

Exclusion criteria

Tumor seedings coming from other origins
Huge peritoneal carcinomatosis (peritoneal score > 25, except for pseudomyxomas)
Peritoneal carcinomatosis progressing rapidly
Presence of extra-abdominal metastases
Patients presenting contraindications to the use of oxaliplatin or irinotecan