Treatment of Abdominal Abscesses With or Without Fibrinolysis

Children's Mercy Hospital Kansas City

Status: Completed

Conditions: Abdominal Abscess; Tissue Plasminogen Activator

Treatments: Procedure: Tissue plasminogen activator abscess flush; Procedure: Saline flush of abscess

Study type: Interventional

Funder types: Other

Identifiers

NCT01597336

11120126

Details and patient eligibility

About

The objective of this study is to evaluate the utility of fibrinolysis when draining an abdominal abscess as defined by length of stay after drainage.

Full description

The hypothesis is that fibrinolysis of a abscess will shorten hospital stay compared to drainage alone.

Enrollment: 92 estimated patients

Sex: All

Ages: Under 17 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients under age 18 found to have an abscess in their abdomen related to perforated appendicitis that requires a drain either prior to or after appendectomy.

Exclusion criteria

• Patients with known immune deficiency per medical record review
• Patients with another condition affecting surgical decision making or recovery
• Patients with drain unable to be placed

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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92 participants in 2 patient groups

Saline only flush of abscess

Active Comparator group

Description:

Saline alone used to flush abscess

Treatment:

Procedure: Saline flush of abscess

Saline plus tPA flush of abscess

Experimental group

Description:

Saline plus tPA used for abscess flush

Treatment:

Procedure: Tissue plasminogen activator abscess flush