Treatment of Acute Asthma in ER With Combination of Systemic Steroids and Inhaled Steroids

Soroka University Medical Center

Status and phase: Unknown; Phase 4

Conditions: Asthma Exacerbation

Treatments: Drug: inhalation of corticosteroids

Study type: Interventional

Funder types: Other

Identifiers

NCT00397267

SOR440906CTIL

Details and patient eligibility

About

We assume that the combination of systemic steroids and inhaled steroid in the first hour of treatment in the ER will decrease the admission rate and improve faster the pulmonary function.

120 patients refferd to the ER due to asthma attack aged 18-60 with PFR < 60% 0o predicted will participate in the study after giving informed consent.

The usual treatment in the ER is inhalation of Beta 2 short acting and I.V solumedrol 120 mg . The study group will recieve in addition 3 inhalation of Budesonide 1000 microgram each during the first hour.

The controlled group will recieve Nacl 0.9% PFR will be followed 0 30 60 120 min.

Full description

Primary end points- PFT improvment and admission rate.

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Asthmatic patients aged 18-60 with PFR < 60% of predicted

Exclusion criteria

• Patients with other chronic diseases
• cardiac renal hepatic etc will be excluded

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)