Treatment of Cerebellar Ataxia With Mesenchymal Stem Cells

National Yang Ming Chiao Tung University

Status and phase: Completed; Phase 2; Phase 1

Conditions: Cerebellar Ataxia

Treatments: Biological: Allogeneic adult adipose-derived mesenchymal stem cells

Study type: Interventional

Funder types: Other

Identifiers

NCT01649687

SB-VGH-201001

Details and patient eligibility

About

The study is to investigate the efficacy and safety of allogenous transplantation of adipose-derived mesenchyma stem cells in patients with cerebellar ataxia.

Enrollment: 7 patients

Sex: All

Ages: 20 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients diagnosed of spinocerebellar ataxia 3 (SCA3) or multiple system atrophy-cerebellar (MSA-C).
• Subject's SARA score at 10~20 points.
• Ages between 20~70 years.
• Signed informed consent from the patient and/or guardian.

Exclusion criteria

• Subjects enrolled in any other cell therapy studies within the past 30 days.
• Pregnancy test positive.
• Subjects deemed to be not suitable for the study by the investigator.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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7 participants in 1 patient group

Mesenchymal stem cells(MSC) treatment

Experimental group

Description:

All subjects will receive allogeneic adult adipose-derived mesenchymal stem cells

Treatment:

Biological: Allogeneic adult adipose-derived mesenchymal stem cells