Treatment of Chronic Leg Ulcer in Outpatient's Department and i Primary Care - Wound Size and Inflammation

University of Oslo (UIO)

Status: Unknown

Conditions: Sharp Debridement; Treatment of Leg Ulcer; Proinflammatory Cytokines

Treatments: Procedure: Sharp debridement

Study type: Interventional

Funder types: Other

Identifiers

NCT01249495

2010/736-2

Details and patient eligibility

About

The purpose of this study is to investigate the rate of wound healing using sharp debridement using curette and to compare between such intensive treatment at hospital and treatment in primary care. A correlation between change in wound size and pro-inflammatory cytokines will also be made.

Full description

Subjects with chronic venous leg ulcers are treated 3 times a week in the hospital for 6 weeks with weekly sharp debridement. Wound size, pro-inflammatory cytokines, smears and photo are made weekly. The treatment countinue thereafter in primary care 3 times a week in 12 weeks. Wound size, pro-inflammatory cytokines, smears and photo are made every 14 day at the hospital.

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Ulcus cruris venosoum
• AAI > 0.9
• age 18-80
• adress Oslo area
• wound size 2.5-100 cm2
• wound duration > 6 weeks.

Exclusion criteria

• Diabetes mellitus
• Immunosuppresion
• antibiotics < 14 days
• local antiseptic treatment < 1 week
• clinical infection.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)