Treatment of Chronic Medium-severe Periodontitis With Mesenchymal Stem Cells Predifferentiated in Osteogenic Direction

Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus

Status and phase: Completed; Phase 2; Phase 1

Conditions: Periodontitis, Chronic

Treatments: Biological: mesenchymal stem cells; Other: standard treatment

Study type: Interventional

Funder types: Other

Identifiers

NCT04446897

IBCE_MSC(periodontitis)

Details and patient eligibility

About

Treatment of chronic medium-severe periodontitis with mesenchymal stem cells and mesenchymal stem cells predifferentiated in osteogenic direction

Full description

The bone defect will be filled with a porous membrane based on bone collagen measuring 5x5 mm or more with mesenchymal stem cells and mesenchymal stem cells predifferentiated in osteogenic direction

Enrollment: 10 patients

Sex: All

Ages: 70 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• chronic medium-severe periodontitis

Exclusion criteria

• pregnancy
• breast-feeding
• acute and chronic infectious diseases: HIV, viral hepatitis, tuberculosis
• mental disorders

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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10 participants in 2 patient groups

mesenchymal stem cells

Experimental group

Description:

standard treatment according to clinical protocols plus mesenchymal stem cells

Treatment:

Biological: mesenchymal stem cells

Other: standard treatment

standard treatment

Active Comparator group

Description:

standard treatment according to clinical protocols

Treatment:

Other: standard treatment