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Treatment of Chronic Mountain Sickness (Exp5300)

C

Centre d'Expertise sur l'Altitude EXALT

Status

Unknown

Conditions

Hypoxia, Altitude

Treatments

Drug: Placebo oral tablet
Drug: Atorvastatin
Drug: Acetazolamide

Study type

Interventional

Funder types

Other

Identifiers

NCT04251364
Expedition5300

Details and patient eligibility

About

This study aims to assess the effect of two drugs for the treatment of chronic mountain sickness in highlanders.

Full description

About 100 million individuals reside at high altitude (>2500m) worldwide, with the largest populations of highlanders being found in South America (Andean), central Asia (Tibetan and Sherpa) and East Africa (Ethiopian). Despite unique adaptations to hypoxia in these populations, chronic mountain sickness (CMS) is a clinical syndrome which is observed in 5-33% of individuals residing permanently at high altitude.Several pharmacological approaches have been proposed in the treatment of EE and CMS. However, few studies show sufficient clinical evidence for safety and efficacy in CMS treatment and most highlanders with CMS remain untreated. The present project aims to better characterize chronic hypoxic responses in highlanders and to evaluate the interest of acetazolamide and statins as potential treatments for chronic mountain sickness.

Enrollment

60 estimated patients

Sex

Male

Ages

18 to 55 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Male
  • Age between 18 and 55 yrs
  • Body mass index <30kg/m²
  • Born at >3500 m, living for >3 years at the local high altitude
  • No diagnosis of cardiorespiratory, metabolic or neurological diseases
  • No drug intake
  • No smoker
  • Chronic mountain sickness score ≥6

Exclusion criteria

  • Diagnosis of cardiorespiratory, metabolic and neurological diseases
  • Systolic > 130 mmHg and/or diastolic > 85 mmHg blood pressure
  • Drug intake
  • Smoker
  • Chronic mountain sickness score <6

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Triple Blind

60 participants in 3 patient groups, including a placebo group

Acetazolamide
Experimental group
Description:
Oral acetazolamide (250 mg/day) intake for 9 months
Treatment:
Drug: Acetazolamide
Atorvastatin
Experimental group
Description:
Oral atorvastatin (40 mg/day) intake for 9 months
Treatment:
Drug: Atorvastatin
Placebo
Placebo Comparator group
Description:
Oral placebo pill (daily) intake for 9 months
Treatment:
Drug: Placebo oral tablet

Trial contacts and locations

1

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Central trial contact

Samuel Verges, PhD

Data sourced from clinicaltrials.gov

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