Treatment of Chronic Postherpetic Pain With Fat Grafting

Odense University Hospital

Status: Completed

Conditions: Post Herpetic Neuralgia; Herpes Zoster

Treatments: Procedure: Fat grafting

Study type: Interventional

Funder types: Other

Identifiers

NCT03584061

S-20180007

Details and patient eligibility

About

This study evaluates the possible beneficial effect of fat grafting for post herpetic neuralgia.

Full description

Herpes Zoster (HZ),is a condition caused by Varizella-Zooster virus (VZV), The disease is caused by reactivation of a latent VZV-infection in the sensory ganglia.

Clinically the condition is characterized by a painful, unilateral, vesicular rash. Pain is the most prominent symptom in around 90% of patients. In 10% of patients this pain remains and becomes chronic.

Post-herpetic neuralgia is a chronic pain syndrome that occurs after the dermal manifestations disappears.

Treatment is complex and mainly topical or systemic. For many patients this is not sufficient and they live with constant pain.

Fat grafting has shown promise in treating several different painful conditions such as post mastectomy pain syndrome, painful scars etc.

This study investigates is PHN can be treated by fat grafting.

Enrollment: 10 patients

Sex: All

Ages: 18 to 100 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age over 18
• Pain in area of former VZV-infection.
• Pain present over 3 months after reactivation of VZV and is present at least 4 days a week and of intensity >3 on the VAS-scale.

Exclusion criteria

• Psychiatric illness that could potentially affect the study.
• Other indication for fat grafting than pain.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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10 participants in 1 patient group

Fat grafting/fat transplant.

Experimental group

Description:

Each patient receives fat grafting to the site of dermal pain. Fat is to be harvested for either the abdomen or the thigh.

Treatment:

Procedure: Fat grafting